Biophysica Incorporated

Phone: 416-784-0463 or Toll Free 1-800-488-2032 from Canada, US and Territories -or- E-mail:

Laser therapy pens


We offer the following wavelengths (in nanometres) available for the following pulsed lasers, modulatable up to 20 megaHertz:. We can supply suitable pulse modulation generators and power supplies. Pulsing and Frequency are important for biological stimulation.  The most biologically important wavelengths are 405, 473, 5312, 630, 650, 980



262, 263, 266, 349, 351, 355, 370, 375, 380




415, 430


438, 440, 442, 447, 457 and 473, 490, nm)


523, 527, 532, 555 nm up to 5 watts


561 nm up to 10 mW


630, 635 nm up to 5 Watts 650, 655,657 nm up to 5 Watts 658 nm up to 50 mW 660, 670, 671, nm up to 5 Watts 690 nm up to 5 Watts IR750, 780 nm at up to 80mW 800, 808 nm at up to 500 mW 810nm at up to 150 Watts 830 nm up to 100 mW 840, 850, 890, nm at up to 8 Watts 904, 905 nm at up to 50 Watts IR 946, 980 nm at up to 2 Watts 1047, 1053, 1064, 1090, nm at 50 mW and 100 mW 1313, 1319, 1320, 1340, 1342, 1550 nm at up to 30 Watts 1610, 1700 nm at up to 200 mW 1900, 1910, 2340 nm at up to 200 mW


High Power Green Lasers

Unbelievably Bright!These are only some of our laser productsDiode pumped continuous wave green lasers operate from included 6 volt wall adaptor for 115vac operation. Fully compliant fan cooled unit is 5″ long x 1-7/8″ wide x 2-3/8″ high. Ready to use.

high power green laser

  • Wavelength……………….532nm (Green)
  • Power Stability………….<±20%
  • Output Mode………………CW
  • Beam Divergence……..<1.4mrad
  • Beam Diameter…………<1mm
  • M2………………………………<2.0
  • Operating Voltage……..4-6VDC
  • AC Power Adaptor Included

LASER10 – >10mw@532nm Class 3B…………..$800 US  

LASER20 – >20mw@532nm Class 3B…………..$1050US

LASER30 – >30mw@532nm Class 3B…………..$1395US

LASERR50 – >50mw@532nm ClassIV……………$1650US

LASER100 – >100mw@532nm ClassIV………….$2450US

Higher powered units are two part construction with forced air cooling operating from an included 9 volt wall adaptor. Fully operating, modules for OEM use.  Spot can be seen several miles away.  Highest power suitable and safe for medical use. Powers up to 5 watts available at this wavelength.

High Power Green Laser

30 Milliwatt Continous or Modulatable Infra-Red Laser Pen

for treatment. High power invisible 30 milliwatt laser at 980 nanometers operates from our international poweer supply.

This laser is a Class 3b device and requires protective eyewear when viewing the beam or any potential direct reflections or scatter.

Intended for experimental use in window bounce systems, target designation, optical x-rays, IR holography and general optical research.

High Powered Visible Red Diode Lasers


Equivalent Color Temp >1,000,000 deg K!!
Range Viewed by Target in Excess of 25 Miles!

Build in a concealable handheld battery operated system as shown.

High brightness visible red beam Illuminates low level clouds. Projects a pencil thin beam for miles.

Universal battery or 115vac operation. Available as functional modules or complete hand held in a gun configuration. Includes range extending adjustable optical colliminator. CLASS 3B.

LGUN1K – 10mw 650nm Laser Gun Kit/Plans……………$650US
LGUN3K – 30mw 650nm Laser Gun Kit/Plans……………$900US

Highly Visible Blue Diode Lasers

BL-3  Blue Diode Module, 473 nm, solid state, 3  mW  $3,000

BL-5  Blue Diode Module, 473 nm, solid state, 5  mW  $3,600BL-15 Module 15 milliwatt blue laser $4,000

USBL-50 Module 50 milliwatt blue laser $11,200

USLow level laser therapy has proven to be  very effective for many conditions that have not responded well to other forms of treatment. LLLT has been thoroughly tested and proven effective in most countries of the world. It is a well accepted and recommended form of treatment in England, Italy, Ireland, the Netherlands, Russia, Israel, Japan, Canada, India, Venezuela and many other countries in Europe, South America and the Far East.A low powered laser procedure does not cut or burn into the skin or affected areas-it stimulates the tissues and promotes healing by penetrating deep into the tissues initializing the process of photobiostimulation. The patient feels no discomfort related to the procedure. The light energy from the low level laser is absorbed in cytochromes and porphyrins within cell mitochondria and cell membranes. A small amount of Singlet Oxygen is produced as a result of the absorption. This is combined with a number of other factors to produce healing as demonstrated in many thousands of clinical study cases. Each case is different and the program utilized varies with the severity on the condition. Typically, patients can expect to feel noticeable improvement after four to six sessions for acute conditions and after six to eight treatments for chronic conditions. While thoroughly tested in many countries outside the U.S., low powered laser therapy has not been approved nor disapproved by the US.  In many instances, low level laser therapy can be a viable alternative to surgery.

Low level laser therapy aims to biostimulate. Because of the low power nature of low level laser therapy the effects are biochemical and not thermal and cannot cause heating and thereby damage to living tissue.


Laser Therapy is the application of red and near infra-red light over injuries or lesions to improve wound / soft tissue healing and give relief for both acute and chronic pain It is now officially referred to as (Low Level Laser Therapy) LLLT

 Laser Therapy is used to





The red and near infrared light (600nm-1000nm) can be produced by laser or high intensity LED

The intensity of LLLT lasers and LED’s is not high like a surgical laser. There is no heating effect

The effect is photochemical (like photosynthisis in plants

Red light aids the production of ATP thereby providing the cell with more energy which in turn means the cell is in optimum condition to play it’s part in a natural healing process

LLLT devices are typically delivering 10mW -200mW (0.2 -> 0.01 Watts). The power density typically ranges from 0.05W/Cm2 -> 5 W/Cm2.

 We can obtain for researchers custom designed infra-red, red, green and blue lasers.

Here are 3 summaries of double blind trials conducted with laser followed by links to pages with more than 30 other clinical trials of LLLT on musculoskeletal disorders, chronic pain and non-healing wounds.

E Liisa Laakso Carolyn Richardson, and Tess Cramond

1: Physiotherapy Department, Royal Brisbane Hospital, Brisbane; 2: Physiotherapy Department, University of Queensland, Brisbane; and 3: Pain Clinic, Royal Brisbane Hospital, Brisbane, Queensland, Australia.

A double-blind, placebo-controlled, random allocation study. 41 subjects, chronic myofascial trigger points in the neck and upper trunk region, five treatment sessions over a two week period, All groups demonstrated significant reductions in pain over the duration of the study.

“Diode Laser in Cervical Myofascial Pain: A Double-Blind Study versus Placebo”

* F. Ceccherelli, * L. Altafini, * G. Lo Castro, * A. Avila, *F. Ambrosio, and * G. P. Giron

*Institute of Anesthesiology and Intensive Care, University of Padua, and the Associazione Italiana per la Ricerca e, l’Aggiornamento Scientif co, Padua, Italy

Double-blind, pulsed infrared, treatment of myofascial pain in the cervical region. 27 subjects, 12 LLLT sessions, alternate days, at each session the four most painful muscular trigger points and five bilateral homometameric acupuncture points were irradiated with 1J. Pain was monitored using McGill pain questionnaire and ScottHuskisson visual analogue scale, pain attenuation in the treated group and a statistically significant difference between the two groups of patients, both at end of therapy and at the 3-month follow-up examination.


Mimmi Logdberg-Anderssont1, Sture Mutzell2, and Ake Hazel3

1: Akersberga Health Care Centre, 2: Danderyd University Hospital, Danderyd, and

3: Vaxholm Health Care Centre, Stockholm, Sweden.

A double-blind study, laser therapy for tendinitis and myofascial pain,176 subjects, 6 treatments during a period of 3-4 weeks.Pain estimated objectively using a pain threshold meter, and subjectively with a visual analogue scale. Laser therapy had a significant, positive effect compared with placebo. Laser treatment was most effective on acute tendinitis.

Parameters for using laser energy

Three parameters are important for clinicians to achieve the best possible therapeutic effects when
using low level laser.

  •         Selection of the correct beneficial Wavelength in nanometers
  •         The use of the correct Power levels
  •         The consistent application of the necessary amount of Energy
  •         Choice of Pulsing Frequency.

Red Light (620 TO 675nm)

  •      Readily absorbed by the mitochondria and therefore potentially stimulatory
  •         Excellent source of stimulation of a range of growth factors
  •         Red Light does not penetrate very effectively below the skin surface and into the tissue below
  •         Red light is the best for wound healing or superficial conditions but is not the most effective way to treat deeper injury

Infrared (Invisible)(780 TO 980nm)

        Absorbed through the cell walls (acting differently between cells) and therefore cell response is more wavelength specific in the infrared range, responding differently to different wavelengths

More penetrative through the tissue, especially the 800 – 980 nm range, therefore this range is selected for treatment through intact skin and pain relief

         Laser therapy is a universal way of treating muscles, tendons, ligaments, joints, connective tissue, and bone and skin tissue with one simple medical instrument. Laser therapy is easy to apply,  non-invasive, painless, drug-free and has no harmful side effects. With laser therapy becoming the modality of choice for the next millennium,

                History of Technology

In 1965, years after Einstein first published the principle of Light Amplification, doctors Sinclair, Knoll, and Mester pioneered the way for therapeutic lasers – lasers that do not cut or destroy tissue, but that heal and have a therapeutic and curative effect on tissue).  For years numerous clinical studies world-wide have attested to the beneficial effects of lasers however, only in the last 10 years are we seeing therapeutic lasers with great increases in power, effectiveness, and decrease in size and cost.

Laser Design Parameters and Tissue Interaction


The tissue effects of lasers can best be characterized by understanding the absorption of light in tissue. There are 3 main components of tissue that affect the absorption of light: water; haemoglobin (pigment that renders blood red); and melanin (pigment that gives skin its natural colour). The absorption curves for these three substances versus the laser wavelength will determine the precise impact that a particular laser will have on tissue (shown in the attached diagram).

This laser light has the unique properties of monochromaticity (a single wavelength), coherence (travels in a straight line), and defined location (concentrated beam) . These properties are what allow lasers to penetrate the skin surface, non-invasively, delivering energy directly to the proper cells, which the cells then convert into chemical energy.

T. Oshiro, a leading expert on therapeutic medical lasers, testifies to the effectiveness of the 905nM laser in his book Low Level Laser Therapy: A Practical Introduction:

“The peak of tissue penetration is around 900 nm. This would appear to make the GaAlAs diode system the most effective LLLT (Low-Level Laser Therapy) system for penetrating to the desired depth. In addition the comparative cost of a GaAlAs makes it both financially and biomedically competitive. The near infrared GaAlAs diode laser systems are even more inexpensive than the HeNe systems, and are also proving more effective in therapy.”

Laser Power

The power of a laser determines how much energy is initially delivered to the tissue surface and along with the wavelength, the power at any given depth of penetration.

Energy density (Joules / centimeter2) is equal to the power of the laser in watts multiplied by the treatment time in seconds, divided by the surface area irradiated in square centimetres.

Energy Density = (Power x Time) / Surface Area

Continuous versus Pulsed Wave Technology
A true pulsed laser  uses a peak power of 30 Watts (30,000 mW) delivering this energy in a fraction of a second (200 billionth’s of a second) for an average power output of 60 mW.

A true pulsed laser system has a peak power which is 500 times greater than the peak power of a continuous wave system of the same rating.

The Biophysica laser system achieves tissue penetration by delivering a powerful burst of energy versus a continuous output, which has difficulty penetrating different densities of tissue.

True Lasers versus Super-luminous Diodes

True lasers such as the Biophysica systems focus all of their energy in one direction in a very concentrated line. A super-luminous diode, on the other hand, diffuses its energy in with a smaller percentage of the energy traveling in the direction of the treatment. A true laser system will deliver more power to the treatment area than a super luminous diode system of exactly the same power rating.

Oshiro’s studies confirm this fact.

“A laser beam travels only in one direction from source, unlike a light bulb. The resulting (true laser) beam has a considerably higher photon density than a monochromatic beam produced by filtering and collimating a conventional multi-wavelength light source. In in vivo tissue targets, several layers of non-homogenous particulate matter have to be penetrated before the beam can reach the LLLT (Low-Level Laser Therapy) targets, and it is the superior photon density of coherent light which ensures this penetration, even though actual coherence may be lost in the first few cell layers.”

Time Per Treatment Session

The benefits in choosing a laser system that will minimize the treatment time are priceless.  The Biophysica laser systems, with its multiple probes allows treatment of up to 5 times the surface area of a single probe system. This translates into an 80% savings in treatment times and consequently the ability to attend to more patients, thereby maximizing the revenue stream possible versus a single probe system.

Simple to Operate

The Biophysica therapeutic laser system has been cleverly designed to be functionally user friendly. The laser settings can be activated by a simple flip of a switch, and the system comes complete with a ready to use manual detailing many of the treatments for common ailments in an easy to follow format.


The Biophysica laser system comes complete with a full 1-year warranty on parts and labour and is built to the highest quality of medical standards.


The Biophysica therapeutic laser system has three levels of safety switches to ensure that the laser is energized only when desired.   Thus ensuring total control of the incident laser beam.

                Biological Tissue Effects

There are four main effects of Low Level Laser Therapy (LLLT): wound healing, anti-inflammation, antalgic (anti-pain) and immunoregulation.

The fact that therapeutic lasers work by supplying energy to the body in the form of photons of light and allowing the body to effect its own repairs allows therapeutic lasers the ability to treat an extensive list of ailments. Ailments that involve skin, tendons, nerves, blood vessels or muscles can be treated with therapeutic lasers.


Frequently Asked Questions

Q:  Is laser (LLLT) therapy scientifically documented?
Q:  How deep into tissue can a laser penetrate?
Q:  What is the relationship between Peak Power and Average
Q:  How do I compute the dosage for a laser treatment?
Q:  What factors should I consider in calculating the appropriate
Q:  Are there harmful side effects/contraindications?
Q:  Does it have to be a laser?

Q:  Is laser (LLLT) therapy scientifically documented?

A:  There are thousands of published studies that describe the positive effects of laser therapy.  These studies range from studies on individual cell types to in vivo double blind cross-over studies.  The areas of study range from wound healing to musculo skeletal conditions and have been conducted on different types of laser devices.  Medline is a very good database search engine that can provide abstracts and can sell literature.  There are also many books on the subject.  One very good text is “Low Level Laser Therapy – Clinical Practice and Scientific Background.”  Written by David Baxter.

Q:  How deep into tissue can a laser penetrate?

A:  The depth of penetration of laser light depends on many parameters such as the laser’s wavelength, the power, the type of device driver (pulse or continuous wave mode), and lastly the technique used.  The higher the wavelength typically the deeper the penetration; however, with wavelengths greater than 930nm the water in the tissue absorbs light and the depth of penetration is drastically reduced.  Secondly, devices of greater power can provide better penetration. Thirdly, the peak power of the unit is the most critical factor in providing depth of penetration. Thus, devices which are true pulsed systems have better penetration versus continuous wave devices because they have greater peak powers. Lastly, the technique of scanning provides for less penetration compared to the in contact method.

Q:  What is the relationship between Peak Power and Average Power?

A:  Average power is computed by multiplying the device’s peak power by the pulse frequency and the pulse duration.  Since continuous wave units are not pulsed, the pulse duration and the pulse frequency are both equal to 1 and thus the unit’s average power will be equal to the peak power. Some manufacturer’s of continuous wave devices have chopped the output to create a pulsing effect.  It is important to note that in continuous wave units increasing the frequency will increase the amount of time that the unit is off and will actually reduce the average power of the unit.  In a true pulsed laser system the opposite is true, increasing the frequency will increase the average power output. The peak power of a continuous wave device is typically measured in milliwatts whereas in a true pulsed laser the peak power is measured in Watts or thousands of milliwatts.

Q:  How do I compute the dosage for a laser treatment?

A:  Typically, clinicians calculate the Energy Density (E.D.) in J/cm2 for a specific treatment using the following equation:

E.D. (J/cm2) = (Average Power (Watts) x Time (seconds)) / Surface Area (cm2)


Time (seconds) = (E.D. (J/cm2) x Surface Area (cm2)) / Average Power (Watts)

The surface area is the beam spot size of the laser device used. Since the beam spot size in true lasers are usually quite small, typical E.D.’s for treatment protocols are in the hundreds of J/cm2. Some manufacturers of weaker power devices will advertise use of E.D.’s less than 10 in order to advertise shorter treatment times.

Since many clinicians use the grid technique and direct contact on the skin, the surface area in the above equation should be 1 cm2.  This makes calculating treatment time very straightforward.  It also becomes evident that devices with higher average powers will take less time to obtain the same energy density.

Q:  What factors should I consider in calculating the appropriate

A:  Since laser energy is absorbed by water, hemoglobin and melanin, different people will require different dosages so that the target tissue of interest obtains the desired energy density. The depth of the target tissue will also play a major part in this decision. Since light energy will be absorbed by other tissues that lie between the target tissue and the
skin surface, one should increase the dose to obtain the desired dosage at the target site.  In order to bio-stimulate the tissue light must reach the target tissue in a sufficient dose otherwise bio-stimulation will not occur.

Q:  Are there harmful side effects/contraindications?

A:  No.  Although one should never shine the laser directly into the eye. Otherwise, we recommend that laser devices not be used on the abdomen of a pregnant woman or directly on any neoplasmic tissue.

Q:  Does it have to be a laser?

A:  Some manufacturers produce devices with super-luminous diodes instead of true laser diodes because they are much cheaper. Super-luminous diodes will produce monochromatic light, but it will not be coherent. Studies have shown that lasers are much more effective because of their superior photon density. The most common application for super-luminous diodes are with superficial wounds. Since these devices are very low powered (approximately 5 to 15 mW) and much of the energy they deliver is scattered, they will require much longer periods of treatment time. Most importantly, super-luminous diodes because of their low photon density will be less effective at delivering energy to tissues below the dermis.


A Laser Diode’s color is dependent on what the wavelength of the emitted light is, just like for LED’s. Laser diodes are capable of emitting visible and infrared (IR) laser beams. The most popular visible laser operates at a wavelength of 650nm. Infrared lasers include 808nm, 980, 1310nm, and 1550nm that are primarily found in medical and telecommunication applications. When using infrared laser diodes, it is necessary to use a PIN photodiode. Since the human eye cannot see IR light, the PIN Photodiode can detect the IR light and has a fast response time for direct measurement of impulse output. The glass window collimates the light beam and it is encased in a hermetically sealed package. Once the case is sealed its contents are protected from hazardous elements, unless it is physically destroyed. The glass envelope is offered in two different styles, flat window and ball lens. Ball shaped lenses are used primarily in fiberoptic applications where it is critical to focus the maximum amount of light into a small glass fiber cable.

Laser Diodes are very sensitive to electro-static discharge (ESD), and will fail if extreme care is not used in handling them. Also, temperature can be a problem. As the temperature increases, the threshold current of the device also increases. A common rule of thumb is if the temperature increases 10o C, the life expectancy of the device will decrease by 50%. Proper grounding and temperature control is recommended.

Photomedicine and Laser Surgery:  808-nm Laser with Exogenous Chromophores for the Treatment of Benign Oral Lesions, Jun 2005, Vol. 23, No. 3: 324-327

O. Marangoni, M.D., Multilaser D. Therapy, Trieste, Italy., M. Melato, M.D., Flow-Cytometry Center, Trieste University, Trieste, Italy., L. Longo, M.D.
General Surgery Institute and Phlebology Center, Siena University, Siena, Italy.
Objective: The aim of this study was to verify the effectiveness and safety of the 808-nm wavelength for use on benign lesions of the oral cavity that are stained with toluidine blue solution. Materials and Methods: The toluidine blue solution according to Mashberg is used in stomatology for the detection of leuko-erythroplasic lesions. In our experience, we have used it to stain even serous cysts, angiomas, and fibromas. We chose a 808-nm wavelength emitted from a power diode laser, because it is well absorbed by the blue color and barely by the healthy mucosa. The non-contact photocoagulation kept the surrounding borders intact when we used the pulsed-emission, 50 ms 7 W, without anesthesia. No sutures were needed. The leukoplasic borders of the lesions were histologically examined before and after the treatment. Results: The vaporized lesions healed completely in about 57 days without any kind of treatment, leaving some slight elastic white scars. A mild edemaerythema followed the treatment for 57 days. Conclusions: The selective results confirm the effectiveness of this therapeutic procedure on pigmented benign lesions, pre-treated with exogenous chromophores and photocoagulated without bleeding, with a minimum energy 808-nm laser.

Links to Other Sites of Interest

European Society for Photobiology

The American Society for Photobiology 

The American Society for Laser Medicine and Surgery  

The World Association for Laser Therapy (WALT) 

The Photomedicine Society



or phone (416)-636-5804 or 1-800-488-2032