and Telomere Regeneration using
High Frequency Pulsed Electro-Magnetic Fields (PEMF)
The Pinealstim Cellular Regenerator emits a pulsed electro-magnetic field, pulsed light pulses and repetitive high voltage pulses and containing within each pulse, high frequency information and free electrons, having an anti-oxidizing benefit. Repetition rate is scanned and controlled by biofeedback circuitry. The energy is powerful and palpable and can penetrate deeply into cellular structures. We are developing a portable model for applying to limbs, abdomen, internal organs, etc.
A major thrust of Biophysica's research since 1992, originally supported by a grant from the National Research Council of Canada, is in regeneration of Pineal, Pituitary and Telomeres using electromagnetic free electron energy, signals and frequencies emitted by the Pinealstim generator. We now have Trans-Cerebral and whole body stimulation devices which emit longitudinal Scalar EM waves. This new technology could be promising in protecting and regenerating telomeres in all organs of the body and we invite interested research investors.
TELEMERES: There are many symptoms of old age, but new research shows there is one main cause behind almost all of them. It’s called a telomere, and it determines the lifespan of every cell in the body.
Every cell in the body contains DNA. And each time a cell divides, it makes a copy of that DNA. The problem is that the process isn’t perfect. Every time a cell divides, it loses a little bit of the DNA at the end of the chromosome. The DNA at the end of the chromosome is called the telomere. A telomere is basically “junk” DNA that keeps the chromosome from unraveling. It’s sort of like the little plastic cap at the end of your shoelace. When the cap on a shoelace wears out, the shoelace unravels and stops functioning. Chromosomes work the same way. Every time a cell divides and the DNA copies, a little bit of the telomere “cap’’ is lost.
Eventually, the telomere becomes too short to hold the DNA together. At this point, the cell can no longer divide and it dies. These dying cells are what cause almost all “old age” diseases. Each species has a limited number of cell divisions, after which the cells stop dividing. This is called the Hayflick Limit.
Research shows the shorter the telomeres are, the more likely you are to suffer from cancer, atherosclerosis, Alzheimer’s disease, osteoarthritis, osteoporosis, macular degeneration, and even skin aging. Dozens of studies link shortened telomeres to deadly diseases. For example…
- Shortened telomeres increase your risk of dying from breast, prostate, colorectal, bladder, neck, lung and kidney cancer.
- Shortened telomeres increase your risk of dying from infectious disease.
- Shortened telomeres increase your risk of heart attack.
- And shortened telomeres increase your risk of obesity and insulin resistance.
Until now scientists believed that there was no way to prevent your telomeres from shortening. They thought the aging process was irreversible. Then two scientists discovered a “rejuvenation technology” that can lengthen telomeres in humans and animals. And according to a review article, “In humans, this would be like restoring the health and vigor of a sickly 80-year-old to that of a young adult!” So how can you lengthen your telomeres so you can live longer and beat nearly all the diseases of old age?
Telomeres are specialized DNA-protein complex at ends of linear chromosomes. They are essential for proper maintenace of chromosomes, and play a major role in aging and cancer. Telomerases are specialized reverse transcriptases that are involved in synthesis of telomeres in most organisms. They are very interesting DNA polymerases in that they carry RNA template within them.
T he excitement over telomerase continues to mount as evidence accumulates that makes the connection between telomere length and cell lifespan likely to be more than a coincidence. The most recent findings show that the age span of cultured cells, normally limited to around 50 to 90 cell doublings--the so-called Hayflick limit, named for the scientist who first observed that the lifespan of cultured cells was finite--can be more than doubled by transfecting them with telomerase genes (A.G. Bodnar et al., Science, 279:349-52, 1998). These findings come on the heels of a series of observations correlating the loss of telomerase activity and/or the shortening of the ends of chromosomes (telomeres) with the loss of proliferative capacity, an observation that holds true in a number of situations: somatic (limited proliferative capacity) as compared to germ cells (larger proliferative capacity); normal tissue (limited) versus malignant tumors (unlimited); and normal T cells versus HIV-infected T cells, whose telomeres resemble those of aged individuals.
Telomere & Telomerase in the News
Turning Back the Strands of Time by Kristin Leutwyler (February 2, 1998)
Telomeres, Telomerase and Cancer by Carol W. Greider & Elizabeth H. Blackburn (February, 1996)
Telomere Without End, Amen by Laura DeFrancesco (March 30, 1998)
Telomere Findings May Yield Tips For Treating Cancer, Geriatric Disorders by Ricki Lewis (Feb. 19, 1996)
Scientists discover cellular 'fountain of youth' (January 13, 1998)
Researchers seek biological key to 'fountain of youth' (November 4, 1996)
An Attack on Aging by Christine Gornan (Jan. 26, 1998 Vol. 151 No. 3)
The Immortality Enzyme by J. Madeleine Nash (Sept. 1, 1997 Vol. 150 N0. 9)
New technique resets the biological clock by Rita Rubin (January 26, 1998)
What causes aging? by Nancy Shute (August 18, 1997)
- Kaare et. al. “Perceived age as clinically useful biomarker of ageing: cohort study.” BMJ 2009;339:b5262
- Brouilette S, Singh R, Thompson J, Goodall A, Samani N. "White cell telomere length and risk of premature myocardial infarction." Arterioscler Thromb Vasc Biol. 2003;23(5):842-6.
- Cawthon, R.M., Smith, K.R., O’Brien, E., Sivatchenko, A., Kerber, R.A., “Association between telomere length in blood and mortality in people aged 60 years or older,” Lancet 2003, 361(9355):393-395
- Xu, et al, “Multivitamin use and telomere length in women,” Am. J. Clin. Nutr. March 11, 2009
- Bishayee, A., “Cancer Prevention and Treatment with Resveratrol:
From Rodent Studies to Clinical Trials,” Cancer Prevention Research
(Philadelphia, Pa.) Apr. 28, 2009
- Roy, et al, “Resveratrol Enhances Ultraviolet B-Induced Cell Death
through Nuclear Factor-kappa B Pathway in Human Epidermoid Carcinoma
A431 Cells,” Biochemical and Biophysical Research Communications 2009
- Klatz, R., Grow Young with Human Growth Hormone, p. 93, Harper
Col¬lins, NY, 1997
- “Topical Use of Teprenone,” Study for patent WO 2006/120646, Sederma
- Cherkas, L., Hunkin, J., et al, “The Association Between Physical Activity
in Leisure Time and Leukocyte Telomere Length,” Arch. Intern. Med.
- Stein, R., “Exercise Could Slow Aging,” Wash. Post Jan. 29, 2009
- Telomeres in Disease: Medicine can prevent telomere erosion which causes cancer. Telomere elongation (using powerful antioxidants) may reverse aging or prevent age-related diseases http://the-scientist.com/2012/05/01/telomeres-in-disease/
Telomeres in Disease: Telomeres have been linked to numerous diseases liver dysfunction and aplastic anemia; telomeres dictate a cell’s life span and might be repaired with Hunza at http://the-scientist.com/2012/05/01/telomeres-in-disease/
Telomere & Telomerase Research Information at http://resolution.colorado.edu/~nakamut/telomere/telomere.html
- One of the Most Promising Anti-Aging Breakthroughs I've Ever Seen Posted By Dr. Mercola | April 18 2011 at http://articles.mercola.com/sites/articles/archive/2011/04/18/is-this-the-key-to-living-longer-than-150-years-old.aspx
- Accelerated telomere shortening is a response to life stress
- Chronicity of stress—is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells. Women with the highest levels of perceived stress have demonstrated telomeres shorter on average by the equivalent of at least one decade of additional aging compared. Elissa S. Epel, Elizabeth H. Blackburn, Jue Lin, Firdaus S. Dhabhar, Nancy E. Adler, Jason D. Morrow, and Richard M. Cawthon,PNAS 2004 101: 17312-17315;
chromosomes can be healed by adding new telomeres
Chromosome healing through terminal deletions generated by de novo telomere additions. 534 independent de novo telomere additions were achieved within a 12-kb region of chromosome by de novo genome rearrangement and addition of a telomere. http://www.pnas.org
- Telomeric Sequences from Various Eukaryotes. In most organisms studied, telomere DNA sequences are tandem array of simple G- rich repeat on the strand running from centromere to telomere.
- Telomerase Gene Sequences
- WWW pages from research groups studying telomere biology.
- Upcoming Meetings & Conferences that cover topics related to telomeres & telomerase
- Some articles about telomerase.
- Telomere DataBase at Washington University. This site is a part of GenLink database at Washington University, and collects telomere related references.
- Biochemistry (Moscow) Vol. 62 (1997)
Special Issue: TELOMERE, TELOMERASE, CANCER, AND AGING This issue contains recent reviews concerning telomere biology. The entire text is available on-line. Nice starting point for understanding recent telomere studies.
- Telomerase and Telomeres [English] [German] (University of Stuttgart, Lab of Prof. Dr. H.-D. Goertz)
- This site has many Shockwave Animations related to telomeres & telomerase. English and German versions differ in organization and contained links....
- Tetrahymena Telomeres and Mitosis by Brian Harmon Brian Harmon is a graduate student in the Sedat lab. He discusses here new evidences suggesting telomeres are important in sister chromatid segregation during mitosis.
of NIH Funded Research Groups [Gopher Search]
of NSF Funded Research Groups [Gopher Search]
- Geron Corporation [Geron News by The BioSpace] [Company News by YAHOO] Geron Corporation is a biopharmaceutical company focused on the development of therapeutic products of aging, including cancer by controlling telomerase activity in cells.
- Interested in telomerase activity assay?
- Boehringer-Mannheim now sells Telomerase RCR ELISA kit.
- Oncor also sells TRAP-eze, an telomerase detection kit. (Order Information)
- Recommendations and Summary from workshop on telomerase activity and early detection of cancer (June 6-7, 1996)
- Aging by Biology 52 Project: Telomere and Telomerase: Their effects on aging
- The Aging Research Centre (ARC) Home Page
Telomere Club: Telomere & Telomerase Research Information, assembled by Toru Nakamura at the University of Colorado, Boulder, contains information on telomere and related gene sequences, and links to web sites of researcher and companies working in this field.
A listing of telomerase research groups with links to investigators' web pages.
Animated telomerase demonstration by Donald Slish of SUNY Plattsburgh.
Frontiers in Bioscience:Science News Digest for Physicians and Scientist with links to resource material.
Telomerase Enzyme: references to reviews and research articles
TelDB has information about telomeric and subtelomeric regions of chromosomes and telomere literature references, including a user interface to the searchable telomere literature database.
Special Issue: TELOMERE, TELOMERASE, CANCER, AND AGING Biochemistry (Moscow) On-Line, World Wide Web version of the international edition of this Russian scientific journal, containing recent reviews on telomere biology. The entire text is available on-line.
Aging Research Centre (ARC) provides a service that allows researchers in this field to find information that is related to the study of the aging process.
This page last updated April 1, 2014
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